Structure and transport mechanism of P5B-ATPases

Structure and transport mechanism of P5B-ATPases

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In human cells, P5B‐ATPases execute export of spermine from lysosomes to the SMEG SF64M3VN Electric Oven - Black 60cm cytosol, but the mechanisms of spermine recognition, uptake and transport remain elusive.Here the authors present cryo‐EM structures of a yeast homolog of human ATP13A2‐5, Ypk9, which Glasses and Goggles depict three separate transport cycle intermediates, including spermine‐bound conformations.